THE CASSIN SACKETT LAB
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Our research focuses on the processes driving evolutionary diversity across spatial and temporal scales.  In particular, much of our current work focuses on novel (e.g., introduced) pathogens that exert strong selection on naive hosts. This strong selection can either lead to reductions in host diversity or elicit adaptation.  For instance, the pathogen causing avian malaria (Plasmodium relictum) was recently introduced to Hawai'i and subsequently caused the rapid decline of native honeycreeper species, including several extinctions. However, some species have recently begun to evolve tolerance to the pathogen.  Similarly, the bacterium causing bubonic plague (Yersinia pestis) was accidentally introduced to western North America, evoking dramatic declines in prairie dog populations.  Recently, some individuals have demonstrated resistance to the pathogen, but resistance has not become widespread across the species' ranges.  We are investigating the genomic underpinnings of this rapid adaptation to pathogens, and exploring the constraints on adaptation. The observation that only a few honeycreeper species have evolved malaria tolerance, and a small number of prairie dogs exhibit plague resistance, suggests that genetic, ecological, and/or spatiotemporal constraints exist on adaptation to pathogens.

Ongoing projects:

Interacting effects of plague and landscape structure on prairie dog genomes
Black-tailed prairie dogs (Cynomys ludovicianus) in the Front Range of Colorado inhabit a fragmented landscape, with populations interspersed with urban development and agriculture.  Periodically, populations are extirpated by a highly virulent bacterial pathogen, Yersinia pestis, which causes sylvatic plague.  Plague causes 95-100% mortality of prairie dog colonies, followed by recolonization that is dependent on the landscape matrix.  Re-colonization can replenish genetic diversity in natural and moderately urbanized colonies, but populations in a highly urban matrix suffer a loss of diversity.  Genomes of surviving animals and colonists show higher heterozygosity than animals present before plague.    (See More)



Rapid evolution of tolerance to avian malaria in Hawai'i 'amakihi
Hawaiian honeycreepers are a classic example of adaptive radiations, but recently many species have declined to the brink of extinction due to the introduction of avian malaria.  Although the disease is highly virulent, one species-- the Hawai'i 'amakihi (Chlorodrepanis virens)-- has evolved some resistance to malaria.  We are working to understand whether resistance is conferred by few or many loci, what type of selection favored the evolution of resistance, and whether patterns are similar among islands and across taxa.  
(See More)



Evolutionary and ecological divergence in Gunnison’s prairie dogs
At the macroevolutionary scale, habitat constraints influencing predator abundance, burrowing ability and plant availability may act as selective agents.  Gunnison’s prairie dogs (C. gunnisoni) are split into two geographically disparate subspecies that occupy distinct habitats and are genetically differentiated.  Using complementary approaches that include population genomics, coalescence theory and ecological niche modeling, we examine the contributions of different selection pressures to genetic diversity across scales.
(See More)



Connectivity in altered landscapes
Connectivity of populations influences the degree to which species maintain genetic diversity and persist despite local extinctions.  Anthropogenic landscape change has fragmented populations of species worldwide, and the front range of Colorado is an example of a landscape influenced by multiple types of habitat change, including urbanization and land conversion to agriculture.  We investigate how these landscape changes influence black-tailed prairie dog dispersal through the landscape matrix.     (See more)


Genomics of plague resistance in prairie dogs
A small number of prairie dogs have recently, in the last ~10-15 years, begun to show signs of resistance to plague.  Very little is known about the genetic basis of this resistance, so we are working to sequence a prairie dog genome to help us understand the genes underlying the ability to survive this deadly disease.  (See more)
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You can find lab publications on ResearchGate and GoogleScholar, and data from published papers on ResearchGate and GitHub.
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